Effect of drug treatment options on the mobility and expression of blaKPC | Zendy

Andrea L. Roth | Zendy; Philip Lister | Zendy; Nancy D. Hanson | Zendy

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Effect of drug treatment options on the mobility and expression of blaKPC

Author(s) -

Andrea L. Roth,

Philip Lister,

Nancy D. Hanson

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt280

Subject(s) - transposition (logic) , antimicrobial , biology , gene expression , drug , gene , in vitro , protein expression , pharmacology , computational biology , genetics , microbiology and biotechnology , computer science , artificial intelligence

Both transposition and increases in gene expression have been implicated in the success of KPC-producing pathogens, but the stimulus required for these phenomena are unknown. It is possible that exposure to antimicrobials during patient treatment increases bla(KPC) expression or induces Tn4401 transposition. The purpose of this study was to determine if exposure to carbapenems or other antimicrobial drug classes could stimulate expression of bla(KPC) or the in vitro transposition of Tn4401.

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