Chitosan-dextran sulphate nanocapsule drug delivery system as an effective therapeutic against intraphagosomal pathogen Salmonella | Zendy

Divya Prakash Gnanadhas | Zendy; Midhun Ben Thomas | Zendy; M. Elango | Zendy; Ashok M. Raichur | Zendy; Dipshikha Chakravortty | Zendy

Open Access

Chitosan-dextran sulphate nanocapsule drug delivery system as an effective therapeutic against intraphagosomal pathogen Salmonella

Author(s) -

Divya Prakash Gnanadhas,

Midhun Ben Thomas,

M. Elango,

Ashok M. Raichur,

Dipshikha Chakravortty

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt252

Subject(s) - salmonella , nanocapsules , chitosan , pathogen , microbiology and biotechnology , drug , dextran , drug delivery , salmonella enterica , chemistry , antibacterial agent , bacteria , pharmacology , biology , antibiotics , nanotechnology , nanoparticle , materials science , biochemistry , genetics , organic chemistry

The ability to target conventional drugs efficiently inside cells to kill intraphagosomal bacteria has been a major hurdle in treatment of infective diseases. We aimed to develop an efficient drug delivery system for combating infection caused by Salmonella, a well-known intracellular and intraphagosomal pathogen. Chitosan-dextran sulphate (CD) nanocapsules were assessed for their efficiency in delivering drugs against Salmonella.

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