Interactions between tenofovir and nevirapine in CD4+ T cells and monocyte-derived macrophages restrict their intracellular accumulation | Zendy

Neill J. Liptrott | Zendy; Paul Curley | Zendy; Darren Moss | Zendy; David Back | Zendy; Saye Khoo | Zendy; Andrew Owen | Zendy

Open Access

Interactions between tenofovir and nevirapine in CD4+ T cells and monocyte-derived macrophages restrict their intracellular accumulation

Author(s) -

Neill J. Liptrott,

Paul Curley,

Darren Moss,

David Back,

Saye Khoo,

Andrew Owen

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt225

Subject(s) - nevirapine , intracellular , tenofovir , pharmacokinetics , virus , monocyte , virology , reverse transcriptase inhibitor , biology , pharmacology , chemistry , human immunodeficiency virus (hiv) , viral disease , antiretroviral therapy , immunology , viral load , sida , genetics

There is no pharmacokinetic interaction between tenofovir and nevirapine, but a higher emergence rate of resistance mutations has been reported when these drugs are coadministered. We sought to examine if there is a potential intracellular interaction that may account for the emergence of resistant virus.

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