Pharmacokinetics of four different brands of colistimethate and formed colistin in rats | Zendy

Huiling He | Zendy; J.-C. Li | Zendy; Roger L. Nation | Zendy; Jovan Jacob | Zendy; Gong Chen | Zendy; H. J. Lee | Zendy; Brian T. Tsuji | Zendy; Philip E. Thompson | Zendy; Kevin Roberts | Zendy; Tony Velkov | Zendy; Jian Li | Zendy

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Pharmacokinetics of four different brands of colistimethate and formed colistin in rats

Author(s) -

Huiling He,

J.-C. Li,

Roger L. Nation,

Jovan Jacob,

Gong Chen,

H. J. Lee,

Brian T. Tsuji,

Philip E. Thompson,

Kevin Roberts,

Tony Velkov,

Jian Li

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt207

Subject(s) - colistin , pharmacokinetics , prodrug , pharmacology , antibiotics , chemistry , medicine , biochemistry

Very different labelling conventions are employed by different products of colistimethate (CMS), an inactive prodrug of colistin that is used as a last-line defence against Gram-negative 'superbugs'. This study examined the chemical composition and pharmacokinetics in rats of four commercial parenteral products of CMS.

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