In vitro pharmacodynamics of human-simulated exposures of ampicillin/sulbactam, doripenem and tigecycline alone and in combination against multidrug-resistant Acinetobacter baumannii | Zendy

Seth T. Housman | Zendy; Mao Hagihara | Zendy; David P. Nicolau | Zendy; Joseph L. Kuti | Zendy

Open Access

In vitro pharmacodynamics of human-simulated exposures of ampicillin/sulbactam, doripenem and tigecycline alone and in combination against multidrug-resistant Acinetobacter baumannii

Author(s) -

Seth T. Housman,

Mao Hagihara,

David P. Nicolau,

Joseph L. Kuti

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt197

Subject(s) - tigecycline , acinetobacter baumannii , doripenem , sulbactam , pharmacodynamics , microbiology and biotechnology , medicine , multiple drug resistance , pharmacology , acinetobacter , meropenem , antimicrobial , drug resistance , biology , antibiotics , antibiotic resistance , pseudomonas aeruginosa , pharmacokinetics , bacteria , imipenem , genetics

Multidrug resistance is common among Acinetobacter baumannii, limiting the available options used to treat infections caused by this organism. The objective of this study was to compare monotherapy and combination therapy with ampicillin/sulbactam, doripenem and tigecycline against multidrug-resistant A. baumannii using an in vitro pharmacodynamic model.

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