Early but limited effects of raltegravir intensification on CD4 T cell reconstitution in HIV-infected patients with an immunodiscordant response to antiretroviral therapy | Zendy

Eugènia Negredo | Zendy; Marta Massanella | Zendy; María C. Puertas | Zendy; María J. Buzón | Zendy; Jordi Puig | Zendy; Núria PérezÁlvarez | Zendy; Josué PérezSantiago | Zendy; Anna Bonjoch | Zendy; José Moltó | Zendy; Antoni Jou | Zendy; Patricia Echeverría | Zendy; Josep M. Llibre | Zendy; Javier MartínezPicado | Zendy; Bonaventura Clotet | Zendy; Julià Blanco | Zendy

Open Access

Early but limited effects of raltegravir intensification on CD4 T cell reconstitution in HIV-infected patients with an immunodiscordant response to antiretroviral therapy

Author(s) -

Eugènia Negredo,

Marta Massanella,

María C. Puertas,

María J. Buzón,

Jordi Puig,

Núria PérezÁlvarez,

Josué PérezSantiago,

Anna Bonjoch,

José Moltó,

Antoni Jou,

Patricia Echeverría,

Josep M. Llibre,

Javier MartínezPicado,

Bonaventura Clotet,

Julià Blanco

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt183

Subject(s) - raltegravir , viral load , cd8 , peripheral blood mononuclear cell , viral replication , t cell , immunology , integrase inhibitor , virology , biology , immune system , virus , medicine , antiretroviral therapy , in vitro , biochemistry

Immune hyperactivation in immunodiscordant patients can induce residual HIV replication and limit CD4 T cell recovery. We assessed the impact of raltegravir intensification on CD4 T cell recovery and viral persistence.

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