Doxycycline suppresses Chlamydia pneumoniae-mediated increases in ongoing immunoglobulin E and interleukin-4 responses by peripheral blood mononuclear cells of patients with allergic asthma | Zendy

Megi Dzhindzhikhashvili | Zendy; Rauno Joks | Zendy; Tamar A. SmithNorowitz | Zendy; Helen G. Durkin | Zendy; Kobkul Chotikanatis | Zendy; Eva Estrella | Zendy; Margaret R. Hammerschlag | Zendy; Stephan Kohlhoff | Zendy

Open Access

Doxycycline suppresses Chlamydia pneumoniae-mediated increases in ongoing immunoglobulin E and interleukin-4 responses by peripheral blood mononuclear cells of patients with allergic asthma

Author(s) -

Megi Dzhindzhikhashvili,

Rauno Joks,

Tamar A. SmithNorowitz,

Helen G. Durkin,

Kobkul Chotikanatis,

Eva Estrella,

Margaret R. Hammerschlag,

Stephan Kohlhoff

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt179

Subject(s) - peripheral blood mononuclear cell , immunoglobulin e , doxycycline , chlamydia , immunology , chlamydophila pneumoniae , chlamydiaceae , antibody , medicine , interleukin 4 , cytokine , biology , microbiology and biotechnology , antibiotics , in vitro , biochemistry

Chlamydia pneumoniae, an obligate intracellular bacterium, has been associated with asthma and the induction of immunoglobulin E (IgE) responses. Whereas tetracyclines have anti-chlamydial activity, their effect on human IgE responses to C. pneumoniae has not been studied.

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