Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission | Zendy

Kevin K. Ariën | Zendy; Muthusamy Venkatraj | Zendy; Johan Míchiels | Zendy; Jurgen Joossens | Zendy; Katleen Vereecken | Zendy; Pieter Van der Veken | Zendy; Saïd Abdellati | Zendy; Vicky Cuylaerts | Zendy; Tania Crucitti | Zendy; Leo Heyndríckx | Zendy; Jan Heeres | Zendy; Koen Augustyns | Zendy; Paul Lewi | Zendy; Guido Vanham | Zendy

Open Access

Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission

Author(s) -

Kevin K. Ariën,

Muthusamy Venkatraj,

Johan Míchiels,

Jurgen Joossens,

Katleen Vereecken,

Pieter Van der Veken,

Saïd Abdellati,

Vicky Cuylaerts,

Tania Crucitti,

Leo Heyndríckx,

Jan Heeres,

Koen Augustyns,

Paul Lewi,

Guido Vanham

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt166

Subject(s) - microbicide , microbicides for sexually transmitted diseases , vaginal microbicide , pre exposure prophylaxis , reverse transcriptase inhibitor , reverse transcriptase , sexual transmission , toxicity , virology , biology , pharmacology , medicine , virus , human immunodeficiency virus (hiv) , population , viral disease , men who have sex with men , rna , sida , biochemistry , environmental health , syphilis , gene , health services

Pre-exposure prophylaxis and topical microbicides are important strategies in the prevention of sexual HIV transmission, especially since partial protection has been shown in proof-of-concept studies. In search of new candidate drugs with an improved toxicity profile and with activity against common non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV, we have synthesized and investigated a library of 60 new diaryltriazine analogues.

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