A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection | Zendy

Sarah D’Alessandro | Zendy; Francesco Silvestrini | Zendy; Koen J. Dechering | Zendy; Yolanda Corbett | Zendy; Silvia Parapini | Zendy; Martijn Timmerman | Zendy; Laura Galastri | Zendy; Nicoletta Basilico | Zendy; Robert W. Sauerwein | Zendy; Pietro Alano | Zendy; Donatella Taramelli | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detection

Author(s) -

Sarah D’Alessandro,

Francesco Silvestrini,

Koen J. Dechering,

Yolanda Corbett,

Silvia Parapini,

Martijn Timmerman,

Laura Galastri,

Nicoletta Basilico,

Robert W. Sauerwein,

Pietro Alano,

Donatella Taramelli

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt165

Subject(s) - gametocyte , plasmodium falciparum , biology , lactate dehydrogenase , malaria , parasite hosting , virology , pharmacology , microbiology and biotechnology , biochemistry , immunology , enzyme , world wide web , computer science

Plasmodium gametocytes, responsible for malaria parasite transmission from humans to mosquitoes, represent a crucial target for new antimalarial drugs to achieve malaria elimination/eradication. We developed a novel colorimetric screening method for anti-gametocyte compounds based on the parasite lactate dehydrogenase (pLDH) assay, already standardized for asexual stages, to measure gametocyte viability and drug susceptibility.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research