Effectiveness of miltefosine treatment in targeting anti-leishmanial HO-1/Nrf-2-mediated oxidative responses in visceral leishmaniasis patients | Zendy

Sushmita Das | Zendy; Krishna Pandey | Zendy; Vidya Nand Rabidas | Zendy; Abhishek Mandal | Zendy; Pradip Das | Zendy

Open Access

Effectiveness of miltefosine treatment in targeting anti-leishmanial HO-1/Nrf-2-mediated oxidative responses in visceral leishmaniasis patients

Author(s) -

Sushmita Das,

Krishna Pandey,

Vidya Nand Rabidas,

Abhishek Mandal,

Pradip Das

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt162

Subject(s) - miltefosine , leishmania donovani , visceral leishmaniasis , oxidative stress , in vivo , transcription factor , leishmaniasis , biology , leishmania , pharmacology , immunology , cancer research , biochemistry , parasite hosting , gene , genetics , world wide web , computer science

Miltefosine, an alkylphosphocholine anti-cancer drug, exhibits direct activity against Leishmania donovani and also promotes anti-leishmanial host immunomodulatory functions. Nuclear factor-erythroid 2-related factor 2 (Nrf-2), a redox-sensitive transcription factor, regulates the host stress responses leading to effective microbial clearance by a positive effect on haem oxygenase-1 (HO-1) enzyme expression/activity. We aimed to investigate the role of miltefosine in regulating HO-1/Nrf-2-mediated oxidative responses in visceral leishmaniasis (VL) patients in vivo and in vitro.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research