Analysis of the tolerance of pathogenic enterococci and Staphylococcus aureus to cell wall active antibiotics | Zendy

Rabia Ladjouzi | Zendy; Alain Bizzini | Zendy; François Lebreton | Zendy; Nicolas Sauvageot | Zendy; Alain Rincé | Zendy; Abdellah Benachour | Zendy; Axel Hartke | Zendy

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Analysis of the tolerance of pathogenic enterococci and Staphylococcus aureus to cell wall active antibiotics

Author(s) -

Rabia Ladjouzi,

Alain Bizzini,

François Lebreton,

Nicolas Sauvageot,

Alain Rincé,

Abdellah Benachour,

Axel Hartke

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt157

Subject(s) - microbiology and biotechnology , enterococcus faecalis , staphylococcus aureus , antibiotics , biology , enterococcus , penicillin , multidrug tolerance , vancomycin , superoxide dismutase , enterococcus faecium , bacteria , enzyme , genetics , biochemistry , biofilm

Tolerance refers to the phenomenon that bacteria do not significantly die when exposed to bactericidal antibiotics. Enterococci are known for their high tolerance to these drugs, but the molecular reasons why they resist killing are not understood. In a previous study we showed that the superoxide dismutase (SOD) is implicated in this tolerance. This conclusion was based on the results obtained with one particular strain of Enterococcus faecalis and therefore the objective of the present communication was to analyse whether dependence of tolerance on active SOD is a general phenomenon for enterococci and another Gram-positive pathogen, Staphylococcus aureus.

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