Open AccessMethod for simultaneous analysis of nine second-line anti-tuberculosis drugs using UPLC-MS/MS
Author(s) -
Minje Han,
Sun Hee Jun,
Jae Ho Lee,
Kyoung Un Park,
Junghan Song,
Sang Hoon Song
Publication year - 2013
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkt154
Subject(s) - chromatography , chemistry , high performance liquid chromatography , formic acid , moxifloxacin , therapeutic drug monitoring , ammonium formate , cycloserine , antibacterial agent , probenecid , pharmacokinetics , pharmacology , antibiotics , medicine , biochemistry
Therapeutic drug monitoring (TDM) of anti-tuberculosis (TB) drugs is beneficial for patients responding slowly to treatment and those with multidrug-resistant TB. We used ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to develop a rapid method for simultaneously measuring the blood concentrations of nine second-line anti-TB drugs: streptomycin, kanamycin, clarithromycin, cycloserine, moxifloxacin, levofloxacin, para-aminosalicylic acid, prothionamide and linezolid.