Method for simultaneous analysis of nine second-line anti-tuberculosis drugs using UPLC-MS/MS | Zendy

Minje Han | Zendy; Sun Hee Jun | Zendy; Jae Ho Lee | Zendy; Kyoung Un Park | Zendy; Junghan Song | Zendy; Sang Hoon Song | Zendy

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Method for simultaneous analysis of nine second-line anti-tuberculosis drugs using UPLC-MS/MS

Author(s) -

Minje Han,

Sun Hee Jun,

Jae Ho Lee,

Kyoung Un Park,

Junghan Song,

Sang Hoon Song

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt154

Subject(s) - chromatography , chemistry , high performance liquid chromatography , formic acid , moxifloxacin , therapeutic drug monitoring , ammonium formate , antibacterial agent , cycloserine , pharmacokinetics , pharmacology , antibiotics , medicine , biochemistry

Therapeutic drug monitoring (TDM) of anti-tuberculosis (TB) drugs is beneficial for patients responding slowly to treatment and those with multidrug-resistant TB. We used ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to develop a rapid method for simultaneously measuring the blood concentrations of nine second-line anti-TB drugs: streptomycin, kanamycin, clarithromycin, cycloserine, moxifloxacin, levofloxacin, para-aminosalicylic acid, prothionamide and linezolid.

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