The role of oxidative and nitrosative bursts caused by azoles and amphotericin B against the fungal pathogen Cryptococcus gattii | Zendy

G. F. Ferreira | Zendy; Ludmila de Matos Baltazar | Zendy; Julliana Ribeiro Alves dos Santos | Zendy; Andrea Souza Monteiro | Zendy; Lúcia Alves de Oliveira Fraga | Zendy; Maria Aparecida de Resende | Zendy; Daniel Assis Santos | Zendy

Open Access

The role of oxidative and nitrosative bursts caused by azoles and amphotericin B against the fungal pathogen Cryptococcus gattii

Author(s) -

G. F. Ferreira,

Ludmila de Matos Baltazar,

Julliana Ribeiro Alves dos Santos,

Andrea Souza Monteiro,

Lúcia Alves de Oliveira Fraga,

Maria Aparecida de Resende,

Daniel Assis Santos

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt114

Subject(s) - cryptococcus gattii , peroxynitrite , ergosterol , superoxide dismutase , lipid peroxidation , amphotericin b , catalase , itraconazole , pharmacology , chemistry , free radical scavenger , biochemistry , antioxidant , microbiology and biotechnology , superoxide , biology , cryptococcosis , enzyme , antifungal

Although the most accepted mechanisms of action of amphotericin B and azoles are related to ergosterol, it is possible that these drugs have other effects on the fungal cell. In the present study, the role of endogenous reactive oxygen species (ROS) and peroxynitrite produced by azoles and amphotericin B in the fungus Cryptococcus gattii were examined.

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