Evaluation of antimicrobial activity of ceftaroline against Clostridium difficile and propensity to induce C. difficile infection in an in vitro human gut model
Author(s) -
Simon D. Baines,
C. H. Chilton,
G. S. Crowther,
S. L. Todhunter,
Jane Freeman,
M. H. Wilcox
Publication year - 2013
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkt107
Subject(s) - clostridium difficile , microbiology and biotechnology , c difficile , antimicrobial , in vitro , clostridiaceae , biology , medicine , antibiotics , biochemistry , toxin
To examine the effects of exposure to ceftaroline or ceftriaxone on the epidemic Clostridium difficile strain PCR ribotype 027 and the indigenous gut microflora in an in vitro human gut model. Additionally, the MICs of ceftriaxone and ceftaroline for 60 C. difficile isolates were determined.
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