Rapid degradation of Streptococcus pyogenes biofilms by PlyC, a bacteriophage-encoded endolysin | Zendy

Yang Shen | Zendy; Thomas Köller | Zendy; Bernd Kreikemeyer | Zendy; Daniel Nelson | Zendy

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Rapid degradation of Streptococcus pyogenes biofilms by PlyC, a bacteriophage-encoded endolysin

Author(s) -

Yang Shen,

Thomas Köller,

Bernd Kreikemeyer,

Daniel Nelson

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt104

Subject(s) - biofilm , microbiology and biotechnology , streptococcus pyogenes , lysin , antibiotics , lysis , biology , bacteria , bacteriophage , chemistry , staphylococcus aureus , biochemistry , genetics , escherichia coli , gene

Streptococcus pyogenes, or Group A streptococcus (GAS), has a propensity to colonize human tissues and form biofilms. Significantly, these biofilms are a contributing mechanism of antibiotic treatment failure in streptococcal disease. In this study, we evaluate a streptococcal-specific bacteriophage-encoded endolysin (PlyC), which is known to lyse planktonic streptococci, on both static and dynamic streptococcal biofilms.

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