Efficacy of doripenem and ertapenem against KPC-2-producing and non-KPC-producing Klebsiella pneumoniae with similar MICs | Zendy

Mao Hagihara | Zendy; Jared L. Crandon | Zendy; Carl Urban | Zendy; David P. Nicolau | Zendy

Open Access

Efficacy of doripenem and ertapenem against KPC-2-producing and non-KPC-producing Klebsiella pneumoniae with similar MICs

Author(s) -

Mao Hagihara,

Jared L. Crandon,

Carl Urban,

David P. Nicolau

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt056

Subject(s) - ertapenem , doripenem , klebsiella pneumoniae , microbiology and biotechnology , carbapenem , biology , minimum inhibitory concentration , meropenem , medicine , antimicrobial , antibiotics , antibiotic resistance , escherichia coli , biochemistry , gene

In the clinical setting, the choice of definitive drug therapy is typically guided by the antimicrobial susceptibility profile of the infecting organism. We evaluated the activity of doripenem and ertapenem against Klebsiella pneumoniae isolates with similar MICs that exhibited KPC-based and non-KPC-based genotypes.

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