An elevated pro-inflammatory cytokine response is linked to development of amphotericin B-induced nephrotoxicity | Zendy

Louis Yi Ann Chai | Zendy; Mihai G. Netea | Zendy; Bee Choo Tai | Zendy; LayWai Khin | Zendy; Alieke G. Vonk | Zendy; Boon Wee Teo | Zendy; H. T. Schlamm | Zendy; Raoul Herbrecht | Zendy; J. Peter Donnelly | Zendy; Peter F. Troke | Zendy; Bart Jan Kullberg | Zendy

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An elevated pro-inflammatory cytokine response is linked to development of amphotericin B-induced nephrotoxicity

Author(s) -

Louis Yi Ann Chai,

Mihai G. Netea,

Bee Choo Tai,

LayWai Khin,

Alieke G. Vonk,

Boon Wee Teo,

H. T. Schlamm,

Raoul Herbrecht,

J. Peter Donnelly,

Peter F. Troke,

Bart Jan Kullberg

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt055

Subject(s) - nephrotoxicity , medicine , amphotericin b , cytokine , amphotericin b deoxycholate , acute kidney injury , creatinine , hazard ratio , gastroenterology , pharmacology , immunology , kidney , antifungal , confidence interval , dermatology , caspofungin

The underlying mechanism for amphotericin B-induced acute kidney injury (AKI) remains poorly understood and may be immunologically mediated. We assessed whether the development of nephrotoxicity is linked to a distinct cytokine profile in patients receiving amphotericin B deoxycholate (AmBD).

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