Activity of BAL30072 alone or combined with -lactamase inhibitors or with meropenem against carbapenem-resistant Enterobacteriaceae and non-fermenters
Author(s) -
Shazad Mushtaq,
Neil Woodford,
Russell Hope,
Rachael Adkin,
David M. Livermore
Publication year - 2013
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkt050
Subject(s) - meropenem , klebsiella pneumoniae , microbiology and biotechnology , enterobacteriaceae , acinetobacter baumannii , carbapenem , pseudomonas aeruginosa , agar dilution , biology , acinetobacter , efflux , antibiotics , escherichia coli , antibiotic resistance , bacteria , minimum inhibitory concentration , gene , biochemistry , genetics
We investigated the activity of BAL30072, a dihydroxypyridone monosulfactam, against carbapenem-resistant Enterobacteriaceae and non-fermenters (i) alone, (ii) combined with BAL29880 (to inhibit AmpC) and/or clavulanate [to inhibit extended-spectrum β-lactamases (ESBLs)] and (iii) combined 1:1 with meropenem.
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