Relationship between CES2 genetic variations and rifampicin metabolism | Zendy

Sang Hoon Song | Zendy; Ho Eun Chang | Zendy; S. H. Jun | Zendy; Kyoung Un Park | Zendy; JaeHo Lee | Zendy; E.-M. Lee | Zendy; Y.-H. Song | Zendy; Junghan Song | Zendy

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Relationship between CES2 genetic variations and rifampicin metabolism

Author(s) -

Sang Hoon Song,

Ho Eun Chang,

S. H. Jun,

Kyoung Un Park,

JaeHo Lee,

E.-M. Lee,

Y.-H. Song,

Junghan Song

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt036

Subject(s) - rifampicin , metabolite , drug metabolism , biology , metabolism , in vivo , enzyme , carboxylesterase , pharmacology , genetics , antibiotics , biochemistry

Rifampicin is known to be deacetylated in vivo, resulting in its metabolite 25-desacetyl rifampicin, but the enzyme metabolizing rifampicin and the association of this process with any genetic variation have not yet been elucidated. In this study, genetic variations of a surrogate enzyme, carboxylesterase 2 (CES2), and their association with the metabolism of this drug, were investigated.

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