A validated ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of polymyxin B in mouse serum and epithelial lining fluid: application to pharmacokinetic studies | Zendy

Junna He | Zendy; Shegan Gao | Zendy; Ming Hu | Zendy; Diana Shu-Lian Chow | Zendy; Vincent H. Tam | Zendy

Open Access

A validated ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of polymyxin B in mouse serum and epithelial lining fluid: application to pharmacokinetic studies

Author(s) -

Junna He,

Shegan Gao,

Ming Hu,

Diana Shu-Lian Chow,

Vincent H. Tam

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks536

Subject(s) - polymyxin b , chromatography , polymyxin , pharmacokinetics , formic acid , chemistry , high performance liquid chromatography , selected reaction monitoring , liquid chromatography–mass spectrometry , tandem mass spectrometry , mass spectrometry , pharmacology , antibiotics , medicine , biochemistry

A rapid, sensitive and robust ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for the quantification of four major polymyxin B components (polymyxin B1, polymyxin B2, polymyxin B3 and isoleucine-polymyxin B1) in serum and epithelial lining fluid (ELF) samples.

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