Mixed infection by Clostridium difficile in an in vitro model of the human gut | Zendy

Simon D. Baines | Zendy; G. S. Crowther | Zendy; S. L. Todhunter | Zendy; Jane Freeman | Zendy; C. H. Chilton | Zendy; Warren N. Fawley | Zendy; Mark H. Wilcox | Zendy

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Mixed infection by Clostridium difficile in an in vitro model of the human gut

Author(s) -

Simon D. Baines,

G. S. Crowther,

S. L. Todhunter,

Jane Freeman,

C. H. Chilton,

Warren N. Fawley,

Mark H. Wilcox

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks529

Subject(s) - clostridium difficile , microbiology and biotechnology , in vitro , feces , in vivo , c difficile , biology , antibiotics , biochemistry

Clostridium difficile infection (CDI) is still a major clinical challenge. Previous studies have demonstrated multiple distinct C. difficile strains in the faeces of patients with CDI; yet whether true mixed CDI occurs in vivo is unclear. In this study we evaluated whether two distinct C. difficile strains could co-germinate and co-proliferate in an in vitro human gut model.

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