High-dose induction liposomal amphotericin B followed by de-escalation is effective in experimental Aspergillus terreus pneumonia | Zendy

Russell E. Lewis | Zendy; N. P. Albert | Zendy; Ga Liao | Zendy; Weijie Wang | Zendy; Randall A. Prince | Zendy; Dimitrios P. Kontoyiannis | Zendy

Open Access

High-dose induction liposomal amphotericin B followed by de-escalation is effective in experimental Aspergillus terreus pneumonia

Author(s) -

Russell E. Lewis,

N. P. Albert,

Ga Liao,

Weijie Wang,

Randall A. Prince,

Dimitrios P. Kontoyiannis

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks521

Subject(s) - aspergillus terreus , amphotericin b , medicine , pharmacology , biology , microbiology and biotechnology , antifungal

Aspergillus terreus is considered to be resistant to amphotericin B (AMB). However, it is unknown whether higher daily doses of liposomal AMB (L-AMB) can overcome this resistance in vivo. We evaluated the efficacy and total lung homogenate AMB concentrations of escalating intravenous doses of L-AMB (3-20 mg/kg daily) versus an induction-de-escalation dosing strategy (10 mg/kg/day ×3 days, then 3 mg/kg/day) in an experimental neutropenic murine model of A. terreus pneumonia.

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