Genotyping using whole-genome sequencing is a realistic alternative to surveillance based on phenotypic antimicrobial susceptibility testing | Zendy

Ea Zankari | Zendy; Henrik Hasman | Zendy; Rolf Sommer Kaas | Zendy; Anne Mette Seyfarth | Zendy; Yvonne Agersø | Zendy; Ole Lund | Zendy; Mikkel V. Larsen | Zendy; Frank M. Aarestrup | Zendy

Open Access

Genotyping using whole-genome sequencing is a realistic alternative to surveillance based on phenotypic antimicrobial susceptibility testing

Author(s) -

Ea Zankari,

Henrik Hasman,

Rolf Sommer Kaas,

Anne Mette Seyfarth,

Yvonne Agersø,

Ole Lund,

Mikkel V. Larsen,

Frank M. Aarestrup

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks496

Subject(s) - genotyping , whole genome sequencing , biology , genome , computational biology , phenotype , genetic testing , antibiotic resistance , molecular diagnostics , genetics , genotype , gene , antibiotics

Antimicrobial susceptibility testing of bacterial isolates is essential for clinical diagnosis, to detect emerging problems and to guide empirical treatment. Current phenotypic procedures are sometimes associated with mistakes and may require further genetic testing. Whole-genome sequencing (WGS) may soon be within reach even for routine surveillance and clinical diagnostics. The aim of this study was to evaluate WGS as a routine tool for surveillance of antimicrobial resistance compared with current phenotypic procedures.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research