Efficacy of voriconazole in a murine model of acute Trypanosoma cruzi infection | Zendy

Julián Ernesto Nicolás Gulin | Zendy; Mackenzie A. Eagleson | Zendy; Miriam Postan | Zendy; Romina A. Cutrullis | Zendy; Héctor Freilij | Zendy; Facundo GarcíaBournissen | Zendy; Patricia B. Petray | Zendy; Jaime Altcheh | Zendy

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Efficacy of voriconazole in a murine model of acute Trypanosoma cruzi infection

Author(s) -

Julián Ernesto Nicolás Gulin,

Mackenzie A. Eagleson,

Miriam Postan,

Romina A. Cutrullis,

Héctor Freilij,

Facundo GarcíaBournissen,

Patricia B. Petray,

Jaime Altcheh

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks478

Subject(s) - voriconazole , trypanosoma cruzi , chagas disease , in vivo , medicine , amastigote , amphotericin b , immunology , pharmacology , biology , microbiology and biotechnology , antifungal , parasite hosting , leishmania , world wide web , computer science

Antifungal triazole derivatives have been studied as possible alternatives for the treatment of Chagas' disease. Voriconazole has demonstrated in vitro activity against Trypanosoma cruzi, but its efficacy in vivo has not yet been tested. We aimed to determine the effect of voriconazole in a murine model of acute T. cruzi infection.

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