3-Hydroxyphthalic anhydride-modified human serum albumin as a microbicide candidate inhibits HIV infection by blocking viral entry | Zendy

Lin Li | Zendy; Jiayin Qiu | Zendy; Lu Lu | Zendy; Shengli An | Zendy; Pengyuan Qiao | Zendy; Shibo Jiang | Zendy; Shuwen Liu | Zendy

Open Access

3-Hydroxyphthalic anhydride-modified human serum albumin as a microbicide candidate inhibits HIV infection by blocking viral entry

Author(s) -

Lin Li,

Jiayin Qiu,

Lu Lu,

Shengli An,

Pengyuan Qiao,

Shibo Jiang,

Shuwen Liu

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks458

Subject(s) - microbicide , cytotoxicity , elispot , human serum albumin , peripheral blood mononuclear cell , biology , virology , immunology , in vitro , human immunodeficiency virus (hiv) , biochemistry

We recently demonstrated that both 3-hydroxyphthalic anhydride (HP)- and maleic anhydride-modified chicken ovalbumin (OVA) could effectively inhibit HIV-1 infection. But because OVA may cause allergy in some human subjects, here we replaced OVA with human serum albumin (HSA) in designing a new anti-HIV-1 agent, HP-HSA, and then tested its anti-HIV-1 activity and cytotoxicity.

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