Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration | Zendy

David Croteau | Zendy; Steven S. Rossi | Zendy; Brookie M. Best | Zendy; Edmund V. Capparelli | Zendy; Ronald J. Ellis | Zendy; David B. Clifford | Zendy; Ann C. Collier | Zendy; Benjamin B. Gelman | Zendy; Christina M. Marra | Zendy; Justin C. McArthur | Zendy; J. Allen McCutchan | Zendy; Susan Morgello | Zendy; David M. Simpson | Zendy; Igor Grant | Zendy; Scott Letendre | Zendy

Open Access

Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration

Author(s) -

David Croteau,

Steven S. Rossi,

Brookie M. Best,

Edmund V. Capparelli,

Ronald J. Ellis,

David B. Clifford,

Ann C. Collier,

Benjamin B. Gelman,

Christina M. Marra,

Justin C. McArthur,

J. Allen McCutchan,

Susan Morgello,

David M. Simpson,

Igor Grant,

Scott Letendre

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks441

Subject(s) - darunavir , chemistry , pharmacology , pharmacokinetics , chromatography , medicine , human immunodeficiency virus (hiv) , virology , viral load , antiretroviral therapy

Higher CSF antiretroviral concentrations may be associated with better control of HIV replication and neurocognitive performance, but only the unbound fraction of antiretrovirals is available to inhibit HIV. Therefore, the objective of this study was to determine total and unbound darunavir concentrations in CSF and compare findings with plasma concentrations as well as the wild-type HIV-1 90% inhibitory concentration (IC(90)).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research