Open AccessPharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques
Author(s) -
Karl Malcolm,
Claire Forbes,
Laura A. Geer,
Ronald S. Veazey,
Lynn R. Goldman,
P. J. Klasse,
J. P. Moore
Publication year - 2012
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dks422
Subject(s) - maraviroc , pharmacokinetics , pharmacology , chemistry , chromatography , medicine , virology , human immunodeficiency virus (hiv)
To investigate the pharmacokinetics (PK) of maraviroc, a CCR5-targeted HIV-1 entry inhibitor, in rhesus macaques following vaginal administration of various maraviroc-loaded aqueous hydroxyethylcellulose (HEC) gels, and to correlate the PK data with efficacy in a single high-dose vaginal SHIV-162P3 challenge model.
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