Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220 | Zendy

S. M. Fetherston | Zendy; L. Geer | Zendy; R. S. Veazey | Zendy; L. Goldman | Zendy; D. J. Murphy | Zendy; T. J. Ketas | Zendy; P. J. Klasse | Zendy; S. Blois | Zendy; P. La Colla | Zendy; J. P. Moore | Zendy; Karl Malcolm | Zendy

Open Access

Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220

Author(s) -

S. M. Fetherston,

L. Geer,

R. S. Veazey,

L. Goldman,

D. J. Murphy,

T. J. Ketas,

P. J. Klasse,

S. Blois,

P. La Colla,

J. P. Moore,

Karl Malcolm

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks415

Subject(s) - vaginal ring , silicone , elastomer , medicine , chemistry , research methodology , population , environmental health , organic chemistry , family planning

The non-nucleoside reverse transcriptase inhibitor MC1220 has potent in vitro activity against HIV type 1 (HIV-1). A liposome gel formulation of MC1220 has previously been reported to partially protect rhesus macaques against vaginal challenge with a simian HIV (SHIV). Here, we describe the pre-clinical development of an MC1220-releasing silicone elastomer vaginal ring (SEVR), including pharmacokinetic (PK) and efficacy studies in macaques.

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