Efficacy and pharmacodynamics of voriconazole combined with anidulafungin in azole-resistant invasive aspergillosis | Zendy

Seyedmojtaba Seyedmousavi | Zendy; Roger J. M. Brüggemann | Zendy; Willem J. G. Melchers | Zendy; Antonius J. M. M. Rijs | Zendy; Paul E. Verweij | Zendy; Johan W. Mouton | Zendy

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Efficacy and pharmacodynamics of voriconazole combined with anidulafungin in azole-resistant invasive aspergillosis

Author(s) -

Seyedmojtaba Seyedmousavi,

Roger J. M. Brüggemann,

Willem J. G. Melchers,

Antonius J. M. M. Rijs,

Paul E. Verweij,

Johan W. Mouton

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks402

Subject(s) - voriconazole , anidulafungin , aspergillosis , aspergillus fumigatus , pharmacology , medicine , azole , combination therapy , echinocandin , microbiology and biotechnology , biology , fluconazole , caspofungin , immunology , antifungal

Azole resistance is an emerging problem in the treatment of Aspergillus fumigatus infections. Combination therapy may be an alternative approach to improve therapeutic outcome in azole-resistant invasive aspergillosis (IA). The in vivo efficacy of voriconazole and anidulafungin was investigated in a non-neutropenic murine model of IA using voriconazole-susceptible and voriconazole-resistant A. fumigatus clinical isolates.

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