Sequential combined treatment with allopurinol and benznidazole in the chronic phase of Trypanosoma cruzi infection: a pilot study | Zendy

Damián PérezMazliah | Zendy; M Alvarez | Zendy; Gretchen Cooley | Zendy; Bruno E. Lococo | Zendy; Graciela Bertocchi | Zendy; Marcos Petti | Zendy; María C. Albareda | Zendy; Alejandro Armenti | Zendy; Rick L. Tarleton | Zendy; Susana A. Laucella | Zendy; Rodolfo Viotti | Zendy

Open Access

Sequential combined treatment with allopurinol and benznidazole in the chronic phase of Trypanosoma cruzi infection: a pilot study

Author(s) -

Damián PérezMazliah,

M Alvarez,

Gretchen Cooley,

Bruno E. Lococo,

Graciela Bertocchi,

Marcos Petti,

María C. Albareda,

Alejandro Armenti,

Rick L. Tarleton,

Susana A. Laucella,

Rodolfo Viotti

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks390

Subject(s) - benznidazole , trypanosoma cruzi , allopurinol , chagas disease , medicine , pharmacology , cd8 , immunology , antigen , parasite hosting , world wide web , computer science

Even though the use of combined drugs has been proved to be effective in other chronic infections, assessment of combined treatment of antiparasitic drugs in human Chagas' disease has not been performed. Herein, a pilot study was conducted to evaluate the tolerance and side effects of a sequential combined treatment of two antiparasitic drugs, allopurinol and benznidazole, in the chronic phase of Trypanosoma cruzi infection.

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