3,4-Dimethoxyphenyl bis-benzimidazole, a novel DNA topoisomerase inhibitor that preferentially targets Escherichia coli topoisomerase I | Zendy

Sandhya Bansal | Zendy; D. K. Sinha | Zendy; Manish Kumar Singh | Zendy; Bokun Cheng | Zendy; Yuk-Ching Tse-Dinh | Zendy; Vibha Tandon | Zendy

Open Access

3,4-Dimethoxyphenyl bis-benzimidazole, a novel DNA topoisomerase inhibitor that preferentially targets Escherichia coli topoisomerase I

Author(s) -

Sandhya Bansal,

D. K. Sinha,

Manish Kumar Singh,

Bokun Cheng,

Yuk-Ching Tse-Dinh,

Vibha Tandon

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks322

Subject(s) - topoisomerase , dna gyrase , topoisomerase iv , escherichia coli , ethidium bromide , dna supercoil , biology , topoisomerase inhibitor , benzimidazole , microbiology and biotechnology , dna , biochemistry , chemistry , dna replication , organic chemistry , gene

Antibiotic resistance in bacterial pathogens is a serious clinical problem. Novel targets are needed to combat increasing drug resistance in Escherichia coli. Our objective is to demonstrate that 2-(3,4-dimethoxyphenyl)-5-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2yl]-1H-benzimidazole (DMA) inhibits E. coli DNA topoisomerase I more strongly than human topoisomerase I. In addition, DMA is non-toxic to mammalian cells at antibiotic dosage level.

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