Retrocyclin inhibits Gardnerella vaginalis biofilm formation and toxin activity | Zendy

Thomas A. Hooven | Zendy; Tara M. Randis | Zendy; Saul Hymes | Zendy; Ryan Rampersaud | Zendy; Adam J. Ratner | Zendy

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Retrocyclin inhibits Gardnerella vaginalis biofilm formation and toxin activity

Author(s) -

Thomas A. Hooven,

Tara M. Randis,

Saul Hymes,

Ryan Rampersaud,

Adam J. Ratner

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks305

Subject(s) - gardnerella vaginalis , bacterial vaginosis , microbiology and biotechnology , biofilm , biology , toxin , in vitro , antimicrobial , microbicide , bacteria , chemistry , immunology , biochemistry , genetics , human immunodeficiency virus (hiv)

Retrocyclins are cyclic antimicrobial peptides that have been shown to be both broadly active and safe in animal models. RC-101, a synthetic retrocyclin, targets important human pathogens and is a candidate vaginal microbicide. Its activity against microbes associated with bacterial vaginosis is unknown.

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