Development of nanocapsules bearing doxorubicin for macrophage targeting through the phosphatidylserine ligand: a system for intervention in visceral leishmaniasis
Author(s) -
Subham Kansal,
Radhika Tandon,
Pankaj Dwivedi,
Pragya Misra,
P. R. P. Verma,
Anuradha Dube,
Prabhat Ranjan Mishra
Publication year - 2012
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dks286
Subject(s) - doxorubicin , in vivo , nanocapsules , pharmacology , phosphatidylserine , nanocarriers , drug delivery , chemistry , visceral leishmaniasis , spleen , biodistribution , drug carrier , leishmania donovani , macrophage , in vitro , immunology , leishmaniasis , biology , medicine , drug , biochemistry , chemotherapy , materials science , membrane , nanotechnology , nanoparticle , phospholipid , microbiology and biotechnology , organic chemistry
The purpose of this study was to explore the applicability, targeting potential and drug delivery to specialized phagocytes via phosphatidylserine (PS)-specific ligand-anchored nanocapsules (NCs) bearing doxorubicin.
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