In vitro evaluation of the potential for resistance development to ceragenin CSA-13 | Zendy

Jacob Pollard | Zendy; Jason Snarr | Zendy; Ved Prakash Chaudhary | Zendy; Jacob D. Jennings | Zendy; H. Shaw | Zendy; Bo Christiansen | Zendy; Jonathan O. Wright | Zendy; Jia Wang | Zendy; Russell E. Bishop | Zendy; Paul B. Savage | Zendy

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In vitro evaluation of the potential for resistance development to ceragenin CSA-13

Author(s) -

Jacob Pollard,

Jason Snarr,

Ved Prakash Chaudhary,

Jacob D. Jennings,

H. Shaw,

Bo Christiansen,

Jonathan O. Wright,

Jia Wang,

Russell E. Bishop,

Paul B. Savage

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks276

Subject(s) - acinetobacter baumannii , microbiology and biotechnology , antimicrobial , bacteria , pseudomonas aeruginosa , ciprofloxacin , staphylococcus aureus , gram negative bacteria , colistin , biology , gram positive bacteria , vancomycin , minimum inhibitory concentration , antibiotics , escherichia coli , biochemistry , genetics , gene

Though most bacteria remain susceptible to endogenous antimicrobial peptides, specific resistance mechanisms are known. As mimics of antimicrobial peptides, ceragenins were expected to retain antibacterial activity against Gram-positive and -negative bacteria, even after prolonged exposure. Serial passaging of bacteria to a lead ceragenin, CSA-13, was performed with representative pathogenic bacteria. Ciprofloxacin, vancomycin and colistin were used as comparators. The mechanisms of resistance in Gram-negative bacteria were elucidated.

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