Efficacy and tolerability of oleylphosphocholine (OlPC) in a laboratory model of visceral leishmaniasis | Zendy

A. Fortin | Zendy; Sarah Hendrickx | Zendy; Vanessa Yardley | Zendy; Paul Cos | Zendy; Herwig Jansen | Zendy; Louis Maes | Zendy

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Efficacy and tolerability of oleylphosphocholine (OlPC) in a laboratory model of visceral leishmaniasis

Author(s) -

A. Fortin,

Sarah Hendrickx,

Vanessa Yardley,

Paul Cos,

Herwig Jansen,

Louis Maes

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks273

Subject(s) - miltefosine , leishmania infantum , visceral leishmaniasis , leishmania , amastigote , leishmania donovani , leishmaniasis , leishmania tropica , pharmacology , paromomycin , medicine , hamster , microbiology and biotechnology , biology , immunology , cutaneous leishmaniasis , aminoglycoside , antibiotics , parasite hosting , world wide web , computer science

The alkylphospholipid oleylphosphocholine (OlPC) is a structural analogue of miltefosine and may represent a potential therapeutic backup for the treatment of visceral leishmaniasis (VL). This laboratory study compared the in vitro and in vivo activity profile of both OlPC and miltefosine.

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