Activity of linezolid and high-dose daptomycin, alone or in combination, in an in vitro model of Staphylococcus aureus biofilm | Zendy

Jorge Parra-Ruiz | Zendy; A. Bravo Molina | Zendy; Alejandro Peña-Monje | Zendy; José HernándezQuero | Zendy

Open Access

Activity of linezolid and high-dose daptomycin, alone or in combination, in an in vitro model of Staphylococcus aureus biofilm

Author(s) -

Jorge Parra-Ruiz,

A. Bravo Molina,

Alejandro Peña-Monje,

José HernándezQuero

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks272

Subject(s) - daptomycin , linezolid , staphylococcus aureus , microbiology and biotechnology , biofilm , antibiotics , methicillin resistant staphylococcus aureus , medicine , pharmacology , chemistry , bacteria , vancomycin , biology , genetics

The aim of the study was to assess the in vitro activity of linezolid and daptomycin, alone and in combination, against three Staphylococcus aureus isolates using a pharmacokinetic/pharmacodynamic (PK/PD) model of biofilm for 3 days.

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