Quinine interactions with tryptophan and tyrosine in malaria patients, and implications for quinine responses in the clinical setting | Zendy

Farida Islahudin | Zendy; Richard J. Pleass | Zendy; Simon V. Avery | Zendy; KangNee Ting | Zendy

Open Access

Quinine interactions with tryptophan and tyrosine in malaria patients, and implications for quinine responses in the clinical setting

Author(s) -

Farida Islahudin,

Richard J. Pleass,

Simon V. Avery,

KangNee Ting

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks253

Subject(s) - quinine , tryptophan , tyrosine , plasmodium falciparum , malaria , pharmacology , chloroquine , medicine , drug , biology , immunology , amino acid , biochemistry

Recent work with the yeast model revealed that the antiprotozoal drug quinine competes with tryptophan for uptake via a common transport protein, causing cellular tryptophan starvation. In the present work, it was hypothesized that similar interactions may occur in malaria patients receiving quinine therapy.

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