Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects | Zendy

Gurudatt Chandorkar | Zendy; Jennifer A. Huntington | Zendy; Mark H. Gotfried | Zendy; Keith A. Rodvold | Zendy; Obiamiwe Umeh | Zendy

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Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects

Author(s) -

Gurudatt Chandorkar,

Jennifer A. Huntington,

Mark H. Gotfried,

Keith A. Rodvold,

Obiamiwe Umeh

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks246

Subject(s) - piperacillin/tazobactam , tazobactam , medicine , piperacillin , antibiotics , pneumonia , microbiology and biotechnology , bacteria , biology , antibiotic resistance , pseudomonas aeruginosa , genetics , imipenem

Appropriate antibiotic exposure at the site of infection is important for clinically effective therapy. This study compared the epithelial lining fluid (ELF) penetration of ceftolozane/tazobactam, which has potent in vitro activity against many Gram-negative pathogens causing nosocomial pneumonia, with that of piperacillin/tazobactam in healthy adult volunteers.

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