Effectiveness of a short (4 day) course of oritavancin in the treatment of simulated Clostridium difficile infection using a human gut model | Zendy

C. H. Chilton | Zendy; Jane Freeman | Zendy; G. S. Crowther | Zendy; S. L. Todhunter | Zendy; Mark H. Wilcox | Zendy

Open Access

Effectiveness of a short (4 day) course of oritavancin in the treatment of simulated Clostridium difficile infection using a human gut model

Author(s) -

C. H. Chilton,

Jane Freeman,

G. S. Crowther,

S. L. Todhunter,

Mark H. Wilcox

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks243

Subject(s) - clostridium difficile , vancomycin , dosing , medicine , microbiology and biotechnology , pharmacology , antibiotics , biology , bacteria , staphylococcus aureus , genetics

We previously demonstrated that 7 days of oritavancin instillation effectively treats Clostridium difficile infection (CDI) in a human gut model. Oritavancin may be more effective than vancomycin due to apparently increased activity against spores. We compared the efficacy of shortened dosing duration (4 days) of oritavancin and vancomycin for CDI treatment using the gut model.

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