HIV-1 genome is often defective in PBMCs and rectal tissues after long-term HAART as a result of APOBEC3 editing and correlates with the size of reservoirs | Zendy

S. Fourati | Zendy; Sidonie Lambert-Niclot | Zendy; Cathia Soulié | Zendy; Isabelle Malet | Zendy; MarcAntoine Valantin | Zendy; Benjamin Descours | Zendy; Zaïna Ait-Arkoub | Zendy; B. Mory | Zendy; Guislaine Carcelain | Zendy; Christine Katlama | Zendy; Vincent Cálvez | Zendy; AnneGeneviève Marcelin | Zendy

Open Access

HIV-1 genome is often defective in PBMCs and rectal tissues after long-term HAART as a result of APOBEC3 editing and correlates with the size of reservoirs

Author(s) -

S. Fourati,

Sidonie Lambert-Niclot,

Cathia Soulié,

Isabelle Malet,

MarcAntoine Valantin,

Benjamin Descours,

Zaïna Ait-Arkoub,

B. Mory,

Guislaine Carcelain,

Christine Katlama,

Vincent Cálvez,

AnneGeneviève Marcelin

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks219

Subject(s) - context (archaeology) , biology , genome , virology , viral load , reverse transcriptase , genetics , virus , polymerase chain reaction , gene , paleontology

Precise characterization of viruses present in reservoirs in long-term pretreated patients will be a major issue to consider in the context of viral eradication. We assessed the frequency of defective viruses present in cellular reservoirs.

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