Evaluation of fluoroquinolone reduced dosage regimens in elderly patients by using pharmacokinetic modelling and Monte Carlo simulations | Zendy

Bruno Leroy | Zendy; M. Uhart | Zendy; Pascal Maire | Zendy; Laurent Bourguig | Zendy

Open Access

Evaluation of fluoroquinolone reduced dosage regimens in elderly patients by using pharmacokinetic modelling and Monte Carlo simulations

Author(s) -

Bruno Leroy,

M. Uhart,

Pascal Maire,

Laurent Bourguig

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks195

Subject(s) - pharmacokinetics , medicine , ofloxacin , levofloxacin , renal function , ciprofloxacin , pharmacodynamics , pharmacology , intensive care medicine , antibiotics , chemistry , biochemistry

Fluoroquinolones are widely used in geriatric patients, but elderly patients are known to be at increased risk of decline in renal function. As fluoroquinolones usually exhibit a dominant renal elimination pathway, reduced dosage regimens are often used in geriatric patients. Our objective was to assess the capability to reach a pharmacokinetic-pharmacodynamic target of efficacy with such reduced dosage regimens of ofloxacin, levofloxacin and ciprofloxacin in elderly patients.

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