The vanadyl ribonucleoside complex inhibits ribosomal subunit formation in Staphylococcus aureus | Zendy

Ashley D. Frazier | Zendy; W. Scott Champney | Zendy

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The vanadyl ribonucleoside complex inhibits ribosomal subunit formation in Staphylococcus aureus

Author(s) -

Ashley D. Frazier,

W. Scott Champney

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks182

Subject(s) - ribosome , ribosomal rna , ribonucleoside , staphylococcus aureus , protein subunit , ribosomal protein , biology , translation (biology) , antibiotics , antimicrobial , eukaryotic small ribosomal subunit , microbiology and biotechnology , biochemistry , bacteria , rna , genetics , messenger rna , gene

The discovery of new antibiotic targets is important to stem the increase in antibiotic resistance to most currently used antimicrobials. The bacterial ribosome is a major target for a large number of antibiotics that inhibit different aspects of translation. Most of these antimicrobial agents also inhibit ribosomal subunit formation as a second cellular target. Precise subunit assembly requires the activity of several distinct RNases for proper rRNA processing. The present work shows that the vanadyl ribonucleoside complex (VRC) inhibited RNases in Staphylococcus aureus involved in ribosomal subunit formation without an effect on translation.

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