The role of eis mutations in the development of kanamycin resistance in Mycobacterium tuberculosis isolates from the Moscow region | Zendy

Marina Gikalo | Zendy; E. Yu. Nosova | Zendy; L. Yu. Krylova | Zendy; A. M. Moroz | Zendy

Open Access

The role of eis mutations in the development of kanamycin resistance in Mycobacterium tuberculosis isolates from the Moscow region

Author(s) -

Marina Gikalo,

E. Yu. Nosova,

L. Yu. Krylova,

A. M. Moroz

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks178

Subject(s) - kanamycin , mycobacterium tuberculosis , tuberculosis , microbiology and biotechnology , biology , drug resistance , multiple drug resistance , virology , antibiotics , medicine , pathology

Kanamycin is an important second-line drug used to treat multidrug-resistant (MDR) tuberculosis (TB). Molecular analysis of the rrs gene seems to be not enough to identify every case of kanamycin resistance. In the present study we evaluated the incidence of eis mutations in kanamycin-resistant Mycobacterium tuberculosis isolates.

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