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The β-barrel assembly machinery (BAM) complex plays a critical role in outer membrane protein (OMP) biogenesis. The outer membrane (OM) of Pseudomonas aeruginosa is centrally involved in mechanisms of antibiotic resistance. This study aimed to identify effects of a synthetic peptide based on conserved sequences in the putative BamA-binding region of BamD, focusing on antibiotic susceptibility and OMP characteristics in P. aeruginosa.

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

A peptide based on homologous sequences of the -barrel assembly machinery component BamD potentiates antibiotic susceptibility of Pseudomonas aeruginosa