Reformulated tenofovir gel for use as a dual compartment microbicide | Zendy

Charlene S. Dezzutti | Zendy; Lisa C. Rohan | Zendy; Lin Wang | Zendy; Kevin Uranker | Zendy; Cory Shetler | Zendy; Marilyn Cost | Zendy; J. D. Lynam | Zendy; David R. Friend | Zendy

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Reformulated tenofovir gel for use as a dual compartment microbicide

Author(s) -

Charlene S. Dezzutti,

Lisa C. Rohan,

Lin Wang,

Kevin Uranker,

Cory Shetler,

Marilyn Cost,

J. D. Lynam,

David R. Friend

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks173

Subject(s) - microbicide , tenofovir , spreadability , microbicides for sexually transmitted diseases , reverse transcriptase inhibitor , chemistry , pharmacology , medicine , virology , human immunodeficiency virus (hiv) , viral load , food science , antiretroviral therapy , population , environmental health , health services

Coital use of 1% tenofovir gel was shown to be modestly effective at preventing HIV transmission when applied vaginally in the CAPRISA 004 trial. Because the gel is hyperosmolar, which would reduce the integrity of the epithelium and induce fluid movement into the lumen, rectal use may not be acceptable. This study evaluated the pre-clinical safety and efficacy of a reformulated (reduced osmolality) tenofovir gel product.

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