Cellular pharmacokinetics and intracellular activity against Listeria monocytogenes and Staphylococcus aureus of chemically modified and nanoencapsulated gentamicin | Zendy

Edurne Imbuluzqueta | Zendy; Sandrine Lemaire | Zendy; Carlos Gamazo | Zendy; Emilio Cornejo Elizondo | Zendy; Nora Ventosa | Zendy; Jaume Veciana | Zendy; Françoise Van Bambeke | Zendy; Marı́a J. Blanco-Prı́eto | Zendy

Open Access

Cellular pharmacokinetics and intracellular activity against Listeria monocytogenes and Staphylococcus aureus of chemically modified and nanoencapsulated gentamicin

Author(s) -

Edurne Imbuluzqueta,

Sandrine Lemaire,

Carlos Gamazo,

Emilio Cornejo Elizondo,

Nora Ventosa,

Jaume Veciana,

Françoise Van Bambeke,

Marı́a J. Blanco-Prı́eto

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks172

Subject(s) - intracellular , gentamicin , listeria monocytogenes , extracellular , staphylococcus aureus , microbiology and biotechnology , chemistry , cytosol , intracellular parasite , antibacterial agent , biochemistry , bacteria , biology , antibiotics , enzyme , genetics

The aim of this study was to investigate different hydrophobic gentamicin formulations [gentamicin-bis(2-ethylhexyl) sulfosuccinate (GEN-AOT), microstructured GEN-AOT (PCA GEN-AOT) and GEN-AOT-loaded poly(lactide-co-glycolide) acid (PLGA) nanoparticles (NPs)] in view of improving its therapeutic index against intracellular bacteria. The intracellular accumulation, subcellular distribution and intracellular activity of GEN-AOT and NPs in different monocytic-macrophagic cell lines were studied.

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