Translational pharmacokinetic modelling and simulation for the assessment of duration of contraceptive use after treatment with miltefosine | Zendy

Thomas P. C. Dorlo | Zendy; Manica Balasegaram | Zendy; Marcos Antônio Barbosa de Lima | Zendy; Peter J. de Vries | Zendy; Jos H. Beijnen | Zendy; Alwin D. R. Huitema | Zendy

Open Access

Translational pharmacokinetic modelling and simulation for the assessment of duration of contraceptive use after treatment with miltefosine

Author(s) -

Thomas P. C. Dorlo,

Manica Balasegaram,

Marcos Antônio Barbosa de Lima,

Peter J. de Vries,

Jos H. Beijnen,

Alwin D. R. Huitema

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks164

Subject(s) - miltefosine , medicine , population , pharmacokinetics , regimen , pharmacology , visceral leishmaniasis , environmental health , leishmaniasis , immunology

Use of miltefosine in the treatment of visceral leishmaniasis (VL) is hampered by its potential teratogenicity. The duration of adequate contraceptive cover in females of child-bearing potential after cessation of a potentially teratogenic drug therapy remains debated. The objective of this study was to provide a rational approach to suggest durations of contraceptive cover for various miltefosine regimens.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research