Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug | Zendy

Eloise Mastrangelo | Zendy; Margherita Pezzullo | Zendy; Tine De Burghgraeve | Zendy; Suzanne J. F. Kaptein | Zendy; Boris Pastorino | Zendy; Kai Dallmeier | Zendy; Xavier de Lamballerie | Zendy; Johan Neyts | Zendy; Alicia M. Hanson | Zendy; David N. Frick | Zendy; Martino Bolognesi | Zendy; Mario Milani | Zendy

Open Access

Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug

Author(s) -

Eloise Mastrangelo,

Margherita Pezzullo,

Tine De Burghgraeve,

Suzanne J. F. Kaptein,

Boris Pastorino,

Kai Dallmeier,

Xavier de Lamballerie,

Johan Neyts,

Alicia M. Hanson,

David N. Frick,

Martino Bolognesi,

Mario Milani

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks147

Subject(s) - flavivirus , virology , ns3 , biology , dengue virus , dengue fever , flaviviridae , helicase , japanese encephalitis , viral replication , antiviral drug , virus , encephalitis , hepatitis c virus , genetics , rna , gene

Infection with yellow fever virus (YFV), the prototypic mosquito-borne flavivirus, causes severe febrile disease with haemorrhage, multi-organ failure and a high mortality. Moreover, in recent years the Flavivirus genus has gained further attention due to re-emergence and increasing incidence of West Nile, dengue and Japanese encephalitis viruses. Potent and safe antivirals are urgently needed.

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