Comparison of two carbapenem-resistant Klebsiella pneumoniae clones: from a contained outbreak in a paediatric population and from a national epidemic | Zendy

Shmuel Benenson | Zendy; Gabriela Warburg | Zendy; Carlos HidalgoGrass | Zendy; V. Temper | Zendy; Allon E. Moses | Zendy; Colin Block | Zendy; Jacob Strahilevitz | Zendy

Open Access

Comparison of two carbapenem-resistant Klebsiella pneumoniae clones: from a contained outbreak in a paediatric population and from a national epidemic

Author(s) -

Shmuel Benenson,

Gabriela Warburg,

Carlos HidalgoGrass,

V. Temper,

Allon E. Moses,

Colin Block,

Jacob Strahilevitz

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks115

Subject(s) - klebsiella pneumoniae , biology , multilocus sequence typing , outbreak , clone (java method) , plasmid , virology , population , microbiology and biotechnology , typing , molecular epidemiology , pulsed field gel electrophoresis , genotype , genetics , medicine , gene , escherichia coli , environmental health

A refractory epidemic of carbapenem-resistant Klebsiella pneumoniae (CRKP) emerged in the adult population at our hospital in 2005, as in most Israeli hospitals. Contemporaneously, a different clone of CRKP caused an easily contained outbreak in a paediatric long-term care facility (LTCF) in Jerusalem. While previously identified host-related risk factors for colonization by these organisms undoubtedly contributed to these outbreaks, it is very likely that bacterial factors might be crucial in explaining the striking differences in transmissibility between the implicated strains. We therefore sought bacterial factors associated with these different epidemiological behaviours.

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