Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression | Zendy

Kyoko Niimi | Zendy; Matthew A. Woods | Zendy; Katsuyuki Maki | Zendy; Hironobu Nakayama | Zendy; Kazuaki Hatakenaka | Zendy; Hiroji Chibana | Zendy; Fumiaki Ikeda | Zendy; Keigo Ueno | Zendy; Masakazu Niimi | Zendy; Richard D. Can | Zendy; Brian C. Monk | Zendy

Open Access

Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression

Author(s) -

Kyoko Niimi,

Matthew A. Woods,

Katsuyuki Maki,

Hironobu Nakayama,

Kazuaki Hatakenaka,

Hiroji Chibana,

Fumiaki Ikeda,

Keigo Ueno,

Masakazu Niimi,

Richard D. Can,

Brian C. Monk

Publication year - 2012

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dks112

Subject(s) - candida glabrata , micafungin , mutant , biology , genetics , mutation , mutagenesis , gene , phenotype , microbiology and biotechnology , candida albicans , antifungal , amphotericin b

A mechanism for the acquisition of high-level echinocandin resistance in Candida glabrata was investigated. FKS mutants were constructed to: determine whether clinically significant micafungin resistance requires a hot-spot mutation in FKS1 and a premature stop codon in FKS2, as was observed in a clinical isolate; select for variants with reduced susceptibility and locate mutations in FKS genes; and assess the roles of FKS1 and FKS2.

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